Microarray Scanner

Products - Microarray Instruments - Microarray Laser Scanners

The new ArrayIt® InnoScan® 700 microarray scanners are the fastest high-resolution 2 color confocal fluorescent microarray scanners available. Dual detection channels allow two-color scanning of an entire glass substrate slide in approximately 3 minutes and 24 substrate slides in a fully automated manner in 100 minutes using the new InnoScan® 700AL. Scanning resolution is adjustable from 3 µm to 40 µm, making it perfect for high-, medium- and low-density microarrays. Dynamic auto focusing guarantees uniform scanning across the entire chip surface. Mapix® Software allows real-time adjustment of scanning intensity, easy channel balancing, data quantitation and data export. This network compatible Windows and Linux system is the most compact laser scanner on the market and weighs just over 10 kg.

Click here to download the user manual for image acquisition and quantification.

Specifications:

Lasers

Thermoelectrically cooled laser diodes with stabilized feedback output

Excitation wavelengths

635 nm and 532 nm (700A and 700AL models)
635 nm (700R model)
532 nm (700G model)

Laser power

Adjustable (2 laser power settings available)

Autofocus

Real-time and automated

Detection

True confocal and high performances digital laser/PMT system

Optical resolution

2.4 µm

Pixel size

3 µm to 40 µm

Scanning time

3.5 min per 22 x 70 mm substrate at 10 µm resolution

Autoloader capacity

24 standard 25 x 76 mm glass substrate slides

Autoloader speed

5 seconds load/unload per substrate slide

Autoloader throughput

100 min for 24 substrate slides

Scan area

Full substrate slide area (22 x 70 mm)

Image format

Standard TIFF (16 bit gray scale)

Barcode reader

All formats

Power supply

88 - 264 VAC

Size (L x D x H)

25 x 45 x 35 cm (models 700A, 700R and 700G)
33 x 60 x 42 cm (model 700AL)

Weight

12 Kg (models 700A, 700R and 700G)
12 Kg (models 700A, 700R and 700G)

Class

Class I laser product

Sensitivity

0.1 fluor/µm²

Dynamic range

>10,000-fold

Uniformity

<5% CV

Format

Open platform glass substrate slides (25 x 76 mm)

Computer interface

Ethernet

Image analysis

Highly accurate grid positioning using automatic spot recognition provide accurate quantification and 16-bit exportable TIFF data

Compatible fluorophores:

Cy5, Alexa 647, Alexa 660 (635 nm); Cy3, Alexa 546, Alexa 555 (532 nm); and custom wavelengths available

Figure 1. The ArrayIt® InnoScan® 700 microarray scanner uses dynamic auto focusing, which greatly reduces background noise and increases signal intensities. This proprietary auto-focusing technology allows the system to adjust to temperature changes, mechanical perturbations and other system changes that would otherwise cause fluctuations in signal and background. The result is highly uniform scanning across the entire chip surface and consistent performance scan after scan.

Quantitation and analysis software is included with every scanner:
Mapix® is a microarray image analysis software application that is both intuitive and easy to use, combining imaging and analysis tools for superior performance.

Highly efficient algorithms provide rapid and effective feature gridding through automatic spot searching and optimal grid alignment.

Automatic spot segmentation ensures high-quality experiment data by selecting relevant pixels and eliminating unwanted ones.
Gridding performance and quantification process are adapted to the high resolution of the InnoScan700 (3m) and therefore to the size of images generated.
Optimal data visualization and quick learning thanks to its highly interactive commands, with full correlation between displayed data, pictures and plots.
Compatible all types of microarrays made by ex-situ and in-situ techniques.
Reads and analyzes interstitial/staggered/orange packing patterned microarrays made by the Protein NanoPrint, Agilent and others.

Batch processing allows analysis of a large number of microarrays per day to boost productivity (available on Version 3.0.0).
Regular software updates are accessible on line to match evolving needs of customers (updates are free for the 1st year).

Configurable for full or modular automation of:

Scanner control
Configuration saving (scan and analysis parameters)
Bar code reading
Quality control by flagging

Compatible with all industry-standard formats and platforms:

Support GAL files and recordable transcripts in both text and GPR formats.
Images are saved as 16-bit TIFF images with all read parameters and can be copied in JPEG format.
Supports image analysis of 16-bit TIFF files from a variety of other scanners.
Platform-independent and runs on all operating systems (Windows, 32- and 64-bit Linux and Macintosh).

Figure 2. The ArrayIt® InnoScan® 700AL laser microarray scanner with autoloader provides high resolution, high-speed fluorescence scanning of all standard glass microarrays. The 700AL scans 24 glass substrate slides (25 x 76 mm) in both channels at 10 µm resolution in 100 minutes. The ArrayIt® InnoScan® 700AL laser microarray scanner is the perfect automated solution to high-throughput microarray scanning for research and diagnostics.

Ordering Information

Catalog ID

Description

Price (US dollars)*

700AL

ArrayIt® simultaneous confocal 2-color fluorescence microarray scanner (635 nm and 532 nm) with 3 µm scan resolution, 24 substrate slide autoloader, Mapix software, computer and monitor, one year warranty, and complimentary software upgrades for one year. Detects Cy3, Alexa 546, Alexa 555, Cy5, Alexa 647, and Alexa 660. Fully compatible with every major brand of open platform microarray products.

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700A

ArrayIt® simultaneous confocal 2-color fluorescence microarray scanner (635 nm and 532 nm) with 3 µm scan resolution, single substrate slide capacity, Mapix software, computer and monitor, one year warranty, and complimentary software upgrades for one year. Detects Cy3, Alexa 546, Alexa 555, Cy5, Alexa 647, and Alexa 660. Fully compatible with every major brand of open platform microarray products.

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700R

ArrayIt® confocal single color fluorescence microarray scanner (635 nm) with 3 µm scan resolution, single substrate slide capacity, Mapix software, computer and monitor, one year warranty, and complimentary software upgrades for one year. Detects Cy5, Alexa 647, and Alexa 660. Fully compatible with every major brand of open platform microarray products.

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700G

ArrayIt® confocal single color fluorescence microarray scanner (532 nm) with 3 µm scan resolution, single substrate slide capacity, Mapix software, computer and monitor, one year warranty, and complimentary software upgrades for one year. Detects Cy3, Alexa 546, and Alexa 555. Fully compatible with every major brand of open platform microarray products.

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MAPIX

ArrayIt® Mapix Microarray Acquisition and Analysis Software for use with Arrayit InnoScan 700 Series Microarray Scanners and other glass substrate slide scanners that generate 16-bit quantifiable TIFF image data. The purchase price provides a single seat working on a single computer. Multiple seat licenses are available upon request. Please contact Arrayit directly for a quote.

6,000.00

Custom laser configurations are possible. Please contact us directly at arrayit@arrayit.com for more information.

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*Please contact us directly for product pricing by email arrayit@arrayit.com, telephone (408) 744-1331, or FAX (408) 744-1711.

*International pricing may vary as much as 30% (or more depending on country) due to import duties, stocking fees and technical support.

Warranty
TeleChem ArrayIt® brand products are sold for research purposes. Extreme care and exact attention should be practiced in the use of the materials described herein. All TeleChem products are subject to extensive quality control and are guaranteed to perform as described when used properly. Any problems with these products should be reported to TeleChem immediately. Our liability is limited to the replacement of the product, or a full refund. Any misuse of this product is the full responsibility of the user, and TeleChem makes no warranty or guarantee under such circumstances.